Actiful® is a novel citrus and pomegranate complex designed to enhance vitality and support an active lifestyle. It is an all-natural ingredient that has been clinically evaluated to improve blood flow and directly enhance energy production, providing immediate and sustained energy.

Natural vitality enhancer

Actiful® is an all-natural citrus and pomegranate complex designed to stimulate a greater blood flow and enhance both short-term and long-term energy systems, boosting vitality and activity.

Clinically proven benefits

Clinically proven benefits

Unique mode of action

Unique mode of action

Stimulant free


Low daily dose of 700 mg

Low daily dose of 600-700 mg

Blood flow and energy

Clinical studies have investigated the effects of Actiful® on blood flow and power output. Results have shown that Actiful® supports active living through a dual action on blood flow and energy production at the mitochondrial level.

Blood flow – oxygen pump

A randomized, placebo-controlled trial (N=48) has shown that a six-week daily intake of 700 mg of Actiful® is able to significantly improve Flow Mediated Dilation (FMD), a direct marker of endothelial function, in individuals 55+. With enhanced FMD, arteries are more flexible and better able to adapt to changes in blood flow, allowing for an improved blood flow and oxygen delivery during physical activity, when muscles require a greater supply of oxygen and nutrients.

Blood flow – oxygen pump

*Significant effect on FMD with daily Actiful® supplementation HFM = High-fat meal

Energy production

A randomized, placebo-controlled trial (N=39) has shown that a four-week daily intake of 700 mg of Actiful® is able to significantly increase power output during exercise in regularly active individuals. Actiful® was shown to affect both aerobic and anaerobic energy systems, demonstrating immediate short-term energy at the start of activity, followed by long-term endurance throughout activity. Actiful® is able to provide targeted energy delivery whenever needed.

Energy production

*10-minute cycling trial to full exhaustion after four-weeks of Actiful® supplementation

Vitality Cycle

Results of the study indicated that those who exercised less than six hours per week experienced a 7.5% increase in power. Therefore, Actiful® is the ultimate holistic ingredient for individuals looking to boost energy levels to support and maintain an active lifestyle.

Additionally, Actiful® supplementation was shown to have an eight-fold decrease in VO2/W ratio (oxygen consumption/power ratio) relative to the placebo group. This reflects an improved efficiency of oxygen usage during mitochondrial respiration. Actiful® can directly augment the efficiency of energy production at the mitochondrial level, supporting vitality.

Dual action effect

Dual action effect

Citrus – Energy

  • Blocks leakage of protons (H+) in the mitochondria
  • Higher levels of H+, increases respiration ability of mitochondria
  • More respiration = enhanced ATP production = more energy

Citrus – Blood flow

  • Activates phosphorylation of Endothelial Nitric Oxide Synthase (eNOS), the key enzyme for Nitric Oxide (NO) synthesis
  • More NO = enhanced blood flow (vasodilation)
  • Greater oxygen availability for muscle cells = more energy (ATP)

Pomegranate – blood flow

  • High levels of nitrate (substrate for NO) = increases NO production = enhances blood flow
  • Strong anti-oxidant
Sans titre

White paper

Download the white paper and discover the scientific evidence around Actiful®.


Researched & developed by BioActor

Actiful® was researched and developed by BioActor, a Dutch life science company that develops health ingredients for functional foods, clinical nutrition, and dietary supplements.

Embedded in the Maastricht Health Campus, BioActor focuses on the core mission of bringing nutrition backed up by real science to consumers, helping them perform better and improve their health and well-being.

Find out more about BioActor, visit the website